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Kyle J. McQuade, Ph.D.
University of Wisconsin, Madison 2003
Office: Wubben 265
Phone: (970) 248-1650
Email: kmcquade@mesastate.edu
Courses
- BIOL 105 and 105L Attributes of Living Systems lecture and lab
- BIOL 302 and 302L Cellular Biology
- BIOL 344 Forensic Molecular Biology
- BIOL 483 Senior Thesis
- EDUC 497D Methods of Teaching Secondary Science
Research and Scholarly Interests Cell motility is essential for many important physiological processes including development, the immune response and cancer metastasis. In order for a cell to move, it must receive and transduce extracellular signals into intracellular chemical reactions that control multiple aspects of cellular behavior. Cellular translocation requires protrusion of the leading edge, a process dependent upon cytoskeletal reorganization. Extension is coupled to formation of new cell-substratum contacts. At the rear of the cell, these contacts are severed, and contraction of the cytoskeleton results in retraction of the trailing edge. My research interests lie in dissecting the molecular details of these events. Current work is focused on two model systems, the social amoebae Dictyostelium discoideum and keratocytes, primary epithelial cells derived from fish scales. Problems in cell motility are addressed using a variety of biochemical and molecular biological techniques as well as time lapse and electron microscopy. I am also interested in expanding the use of these and other model systems in the academic laboratory.
Publications
Selected Papers:
McQuade KJ , Beauvais DM, Burbach BJ and AC Rapraeger. 2006. Syndecan-1 regulates α vβ 5 integrin activity in B82L fibroblasts. J Cell Sci. 119 :2445-56.
McQuade KJ and AC Rapraeger. 2003. Syndecan-1 transmembrane and extracellular domains have unique and distinct roles in cell spreading. J Biol Chem . 278(47):46607-15.
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